_ _ _ _ _ _ Artur ¯ ¯ _ _ _ _ _ _Góra¯ ¯ ¯

 

 

Head of the Tunneling Group

Artur Gora received Ph.D. degree in Chemistry in 2002 from the Jagiellonian University in Poland. In 2004 he was awarded a JSPS fellowship, and from 2004 to 2006 he was working at the National Institute of Advanced Industrial Science and Technology in Japan. From 2010 to 2013, he has been Marie Curie fellow at the Loschmidt Laboratories of the Masaryk University in Brno, Czech Republic. He is a leader of Tunneling Group focused on protein engineering, drug design and software development facilitating molecular dynamic simulations results analysis and interpretation. Since 2016 he is the Deputy Director for Science at Biotechnology Centre, Silesian University of Technology in Poland.

 

 

 

Important publications

Bzówka M., Mitusińska K., Raczyńska A., Samol A., Tuszyński J.A., Góra A. Structural and Evolutionary Analysis Indicate that the SARS-CoV-2 Mpro is a Challenging Target for Small-Molecule Inhibitors Design https://doi.org/10.1101/2020.02.27.968008  ARTICLEOpen Access

Mitusińska, K.; Skalski, T.; Góra, A. Simple Selection Procedure to Distinguish between Static and Flexible Loops. Int J Mol Sci 2020, 21, 2293, doi:10.3390/ijms21072293 ARTICLEOpen Access

Papaj, K.; Kasprzycka, A.; Góra, A.; Grajoszek, A.; Rzepecka, G.; Stojko, J.; Barski, J.-J.; Szeja, W.; Rusin, A. Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell. J Pharm Biomed Anal 2020, 185, 113216, doi:10.1016/J.JPBA.2020.113216. ARTICLEOpen Access

Mitusińska, K.; Raczyńska, A.; Bzówka, M.; Bagrowska, W.; Góra, A. Applications of water molecules for analysis of macromolecule properties. Comput Struct Biotechnol J 2020, 18, 355–365, doi:10.1016/j.csbj.2020.02.001. ARTICLEOpen Access

Magdziarz, T.; Mitusińska, K.; Bzówka, M.; Raczyńska, A.; Stańczak, A.; Banas, M.; Bagrowska, W.; Góra, A. AQUA-DUCT 1.0: structural and functional analysis of macromolecules from an intramolecular voids perspective. Bioinformatics 2019, doi:10.1093/bioinformatics/btz946, ARTICLEOpen Access

Subramanian, K.; Mitusińska, K.; Raedts, J.; Almourfi, F.; Joosten, H.-J.; Hendriks, S.; Sedelnikova, S. E.; Kengen, S. W. M.; Hagen, W. R.; Góra, A.; Martins dos Santos, V. A. P.; Baker, P. J.; van der Oost, J.; Schaap, P. J. Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase. Biomolecules 2019, 9, 212, doi:10.3390/biom9060212. ARTICLEOpen Access

Mitusińska, K.; Magdziarz, T.; Bzówka, M.; Stańczak, A.; Gora, A.; Mitusińska, K.; Magdziarz, T.; Bzówka, M.; Stańczak, A.; Gora, A. Exploring Solanum tuberosum Epoxide Hydrolase Internal Architecture by Water Molecules Tracking. Biomolecules 2018, 8, 143, doi:10.3390/biom8040143. ARTICLEOpen Access

Baaden, M.; Barboiu, M.; Bill, R. M.; Casanova, S.; Chen, C.-L.; Conner, M.; Freger, V.; Gong, B.; Góra, A.; Hinds, B.; Horner, A.; Hummer, G.; Kumar, M.; Lokesh, M.; Mitra, S.; Noy, A.; Pohl, P.; Sadet, A.; Sansom, M.; Törnroth-Horsefield, S.; Vashisth, H. Structure and function of natural proteins for water transport: general discussion. Faraday Discuss 2018, 209, 83–95, doi:10.1039/C8FD90019A. ARTICLE

Baaden, M.; Borthakur, M. P.; Casanova, S.; Coalson, R.; Freger, V.; Gonzalez, M.; Góra, A.; Hinds, B.; Hirunpinyopas, W.; Hummer, G.; Kumar, M.; Lynch, C.; Murail, S.; Noy, A.; Sansom, M.; Song, Q.; Vashisth, H.; Vögele, M. The modelling and enhancement of water hydrodynamics: general discussion. Faraday Discuss 2018, 209, 273–285, doi:10.1039/C8FD90021C. ARTICLE

Płuciennik, A.; Stolarczyk, M.; Bzówka, M.; Raczyńska, A.; Magdziarz, T.; Góra, A. BALCONY: an R package for MSA and functional compartments of protein variability analysis. BMC Bioinformatics 2018, 19, 300, doi:10.1186/s12859-018-2294-z. ARTICLEOpen Access

Subramanian, K.; Góra, A.; Spruijt, R.; Mitusińska, K.; Suarez-Diez, M.; Martins dos Santos, V.; Schaap, P. J. Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access. PLoS One 2018, 13, e0198990. ARTICLEOpen Access

Magdziarz, T.; Mitusińska, K.; Gołdowska, S.; Płuciennik, A.; Stolarczyk, M.; Lugowska, M.; Góra, A. AQUA-DUCT: A ligands tracking tool. Bioinformatics 2017, 33, 2045–2046, doi:10.1093/bioinformatics/btx125. ARTICLE

Brezovsky, J.; Babkova, P.; Degtjarik, O.; Fortova, A.; Gora, A.; Iermak, I.; Rezacova, P.; Dvorak, P.; Kuta Smatanova, I.; Prokop, Z.; Chaloupkova, R.; Damborsky, J.  Engineering a de Novo Transport Tunnel. ACS Catal 2016, 6, 7597–7610, doi:10.1021/acscatal.6b02081. ARTICLE

Kozlikova, B.; Sebestova, E.; Sustr, V.; Brezovsky, J.; Strnad, O.; Daniel, L.; Bednar, D.; Pavelka, A.; Manak, M.; Bezdeka, M.; Benes, P.; Kotry, M.; Gora, A.; Damborsky, J.; Sochor, J. CAVER Analyst 1.0: Graphic tool for interactive visualization and analysis of tunnels and channels in protein structures. Bioinformatics 2014, 30, 2684–2685, doi:10.1093/bioinformatics/btu364. ARTICLE.

Gora, A.; Brezovsky, J.; Damborsky, J. Gates of enzymes. Chem Rev 2013, 113, 5871–5923, doi:10.1021/cr300384w. ARTICLEOpen Access

Hasan, K.; Gora, A.; Brezovsky, J.; Chaloupkova, R.; Moskalikova, H.; Fortova, A.; Nagata, Y.; Damborsky, J.; Prokop, Z. The effect of a unique halide-stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58. In FEBS Journal; 2013; Vol. 280, pp. 3149–3159.

Brezovsky, J.; Chovancova, E.; Gora, A.; Pavelka, A.; Biedermannova, L.; Damborsky, J. Software tools for identification, visualization and analysis of protein tunnels and channels. Biotechnol Adv 2013, 31, 38–49. ARTICLE

Chovancova, E.; Pavelka, A.; Benes, P.; Strnad, O.; Brezovsky, J.; Kozlikova, B.; Gora, A.; Sustr, V.; Klvana, M.; Medek, P.; Biedermannova, L.; Sochor, J.; Damborsky, J. CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures. PLoS Comput Biol 2012, 8, doi:10.1371/journal.pcbi.1002708. ARTICLEOpen Access

Biedermannová, L.; Prokop, Z.; Gora, A.; Chovancová, E.; Kovács, M.; Damborský, J.; Wade, R. C. A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB. J Biol Chem 2012, 287, 29062–29074, doi:10.1074/jbc.M112.377853.

Software

  

More informations

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Contact

Artur.Gora(at)polsl.pl

or

a.gora(at)tunnelinggroup.pl