Artur Gora received Ph.D. degree in Chemistry in 2002 from the Jagiellonian University in Poland. In 2004 he was awarded a JSPS fellowship, and from 2004 to 2006 he was working at the National Institute of Advanced Industrial Science and Technology in Japan. From 2010 to 2013, he has been Marie Curie fellow at the Loschmidt Laboratories of the Masaryk University in Brno, Czech Republic. Since 2014 he is a leader of Tunneling Group located in Biotechnology Centre, Silesian University of Technology. His main works are focused on protein engineering, inhibitors and drug design and software development facilitating molecular dynamic simulations results analysis and interpretation. Between 2016 and 2019 he was the Deputy Director for Science at Biotechnology Centre, Silesian University of Technology in Poland.
Dorrazehi G.M.; Winkle M.; Desmet M.; Stroobant V.; Tanriver G.; Degand H.; Evrard D.; Desguin B.; Morsomme P.; Biboy J.; Gray J.; Mitusińska K.; Góra A.; Vollmer W.; Soumillion P.; PBP-A, a cyanobacterial DD-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli. Scientific Reports. 2024, 14, 13999 doi: 10.1038/s41598-024-64806-x. ARTICLEOpen Access
Skalski T.; Zając E.; Jędrszczyk E.; Papaj K.; Kohyt J.; Góra A.; Kasprzycka A.; Shytum D.; Skowera B.; Ziernicka-Wojtaszek A.. Effects of γ-polyglutamic acid on grassland sandy soil properties and plant functional traits exposed to drought stress. Scientific Reports 2024, 14, 3769 doi: 10.1038/s41598-024-54459-1. ARTICLEOpen Access
Bzówka M.; Bagrowska W.; Góra A.; Recent Advances in Studying Toll-like Receptors with the Use of Computational Methods. J. Chem. Inf. Model., 2023, 63, 12, 3669–3687 doi: 10.1021/acs.jcim.3c00419 ARTICLEOpen Access
Raczyńska A.; Kapica P.; Papaj K.; Stańczak A.; Shyntum D.; Spychalska P.; Byczek-Wyrostek A.; Góra A.; Transient binding sites at the surface of haloalkane dehalogenase LinB as locations for fine-tuning enzymatic activity. PLoS ONE 2023 18(2), e0280776. doi: 10.1371/journal.pone.0280776 ARTICLEOpen Access
Bzówka M.; Mitusińska K.; Raczyńska A.; Skalski T.; Samol A.; Bagrowska W.; Magdziarz T.; Góra A.; Evolution of tunnels in α/β-hydrolase fold proteins—What can we learn from studying epoxide hydrolases? PLOS Computational Biology 2022, 18 (5), e1010119 doi: 10.1371/journal.pcbi.1010119 ARTICLEOpen Access
Mitusińska K.; Bzówka M.; Magdziarz T.; Góra A.; Geometry-Based versus Small-Molecule Tracking Method for Tunnel Identification: Benefits and Pitfalls. J. Chem. Inf. Model. 2022, 62, 24, 6803–6811. doi: 10.1021/acs.jcim.2c00985 ARTICLEOpen Access
Mitusińska K.; Góra A.; Bogdańska A.; Rożdżyńska-Świątkowska A.; Tylki-Szymańska ; Jezela-Stanek A.; Structural analysis of the effect of Asn107Ser mutation on Alg13 activity and Alg13-Alg14 complex formation and expanding the phenotypic variability of ALG13-CDG. Biomolecules 2022, 12(3), 398 doi: 10.3390/biom12030398 ARTICLEOpen Access
Papaj K.; Spychalska P.; Kapica P.; Fisher A.; Nowak J.; Bzówka M.; Sellner M.; Lill M.A.; Smieško ; Góra A.; Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease. PloS ONE 2022, 17 (1), e0262482 doi: 10.1371/journal.pone.0262482 ARTICLEOpen Access
Mitusińka K.; Wojsa P.; Bzówka M.; Raczyńska A.; Bagrowska W.; Samol A.; Kapica P.; Góra A.; Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network. Computational and Structural Biotechnology Journal 2022, 20, 193-205 doi: 10.1016/j.csbj.2021.10.042 ARTICLEOpen Access
Papaj K.; Spychalska P.; Hopko K.; Kapica P.; Fisher A.; Lill M.A.; Bagrowska W.; Nowak J.; Szleper K.; Smieško M.; Kasprzycka A.; Góra A.; Investigation of Thiocarbamates as Potential Inhibitors of the SARS-CoV-2 Mpro. Pharmaceuticals 2021, 14(11), 1153 doi: 10.3390/ph14111153 ARTICLEOpen Access
Bzówka M.; Mitusińska K.; Hopko K.; Góra A.; Computational insights into the known inhibitors of human soluble epoxide hydrolase. Drug Discovery Today 2021, 26(8):1914-1921 doi: 1016/j.drudis.2021.05. ARTICLEOpen Access
Mitusińska K.; Raczyńska A.; Wojsa P.; Bzówka M.; Góra A.; AQUA-DUCT: Analysis of Molecular Dynamics Simulations of Macromolecules with the use of Molecular Probes [Article v1. 0]. Living Journal of Computational Molecular Science 2021, 2 (1), 21383 doi: 10.33011/livecoms.2.1.21383 ARTICLEOpen Access
Fischer A.; Sellner M.; Mitusińska K.; Bzówka M.; Lill M. A.; Góra A.; Smieško M.; Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2 Int. J. Mol. Sci. 2021, 22(4), 2065 doi: 10.3390/ ijms22042065 ARTICLEOpen Access
Jezela-Stanek A.; Blaz W.; Góra A.; Bochenska M.; Kusmierska K.; Sykut-Cegielska J.;, Proteins Structure Models in the Evaluation of Novel Variant (C.472_477del) in the MOSC2 Gene. Diagnostics 2020, 10, 821 doi:10.3390/diagnostics10100821 ARTICLEOpen Access
Bzówka M., Mitusińska K., Raczyńska A., Samol A., Tuszyński J.A., Góra A. Structural and Evolutionary Analysis Indicate that the SARS-CoV-2 Mpro is a Challenging Target for Small-Molecule Inhibitors Design , Int. J. Mol. Sci. 2020, 21(7), 3099 doi: 10.3390/ijms21093099. ARTICLEOpen Access
Mitusińska, K.; Skalski, T.; Góra, A. Simple Selection Procedure to Distinguish between Static and Flexible Loops. Int J Mol Sci 2020, 21, 2293, doi:10.3390/ijms21072293 ARTICLEOpen Access
Papaj, K.; Kasprzycka, A.; Góra, A.; Grajoszek, A.; Rzepecka, G.; Stojko, J.; Barski, J.-J.; Szeja, W.; Rusin, A. Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell. J Pharm Biomed Anal 2020, 185, 113216, doi:10.1016/J.JPBA.2020.113216. ARTICLEOpen Access
Mitusińska, K.; Raczyńska, A.; Bzówka, M.; Bagrowska, W.; Góra, A. Applications of water molecules for analysis of macromolecule properties. Comput Struct Biotechnol J 2020, 18, 355–365, doi:10.1016/j.csbj.2020.02.001. ARTICLEOpen Access
Magdziarz, T.; Mitusińska, K.; Bzówka, M.; Raczyńska, A.; Stańczak, A.; Banas, M.; Bagrowska, W.; Góra, A. AQUA-DUCT 1.0: structural and functional analysis of macromolecules from an intramolecular voids perspective. Bioinformatics 2019, doi:10.1093/bioinformatics/btz946, ARTICLEOpen Access
Subramanian, K.; Mitusińska, K.; Raedts, J.; Almourfi, F.; Joosten, H.-J.; Hendriks, S.; Sedelnikova, S. E.; Kengen, S. W. M.; Hagen, W. R.; Góra, A.; Martins dos Santos, V. A. P.; Baker, P. J.; van der Oost, J.; Schaap, P. J. Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase. Biomolecules 2019, 9, 212, doi:10.3390/biom9060212. ARTICLEOpen Access
Mitusińska, K.; Magdziarz, T.; Bzówka, M.; Stańczak, A.; Gora, A.; Mitusińska, K.; Magdziarz, T.; Bzówka, M.; Stańczak, A.; Gora, A. Exploring Solanum tuberosum Epoxide Hydrolase Internal Architecture by Water Molecules Tracking. Biomolecules 2018, 8, 143, doi:10.3390/biom8040143. ARTICLEOpen Access
Baaden, M.; Barboiu, M.; Bill, R. M.; Casanova, S.; Chen, C.-L.; Conner, M.; Freger, V.; Gong, B.; Góra, A.; Hinds, B.; Horner, A.; Hummer, G.; Kumar, M.; Lokesh, M.; Mitra, S.; Noy, A.; Pohl, P.; Sadet, A.; Sansom, M.; Törnroth-Horsefield, S.; Vashisth, H. Structure and function of natural proteins for water transport: general discussion. Faraday Discuss 2018, 209, 83–95, doi:10.1039/C8FD90019A. ARTICLE
Baaden, M.; Borthakur, M. P.; Casanova, S.; Coalson, R.; Freger, V.; Gonzalez, M.; Góra, A.; Hinds, B.; Hirunpinyopas, W.; Hummer, G.; Kumar, M.; Lynch, C.; Murail, S.; Noy, A.; Sansom, M.; Song, Q.; Vashisth, H.; Vögele, M. The modelling and enhancement of water hydrodynamics: general discussion. Faraday Discuss 2018, 209, 273–285, doi:10.1039/C8FD90021C. ARTICLE
Płuciennik, A.; Stolarczyk, M.; Bzówka, M.; Raczyńska, A.; Magdziarz, T.; Góra, A. BALCONY: an R package for MSA and functional compartments of protein variability analysis. BMC Bioinformatics 2018, 19, 300, doi:10.1186/s12859-018-2294-z. ARTICLEOpen Access
Subramanian, K.; Góra, A.; Spruijt, R.; Mitusińska, K.; Suarez-Diez, M.; Martins dos Santos, V.; Schaap, P. J. Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access. PLoS One 2018, 13, e0198990. ARTICLEOpen Access
Magdziarz, T.; Mitusińska, K.; Gołdowska, S.; Płuciennik, A.; Stolarczyk, M.; Lugowska, M.; Góra, A. AQUA-DUCT: A ligands tracking tool. Bioinformatics 2017, 33, 2045–2046, doi:10.1093/bioinformatics/btx125. ARTICLE
Brezovsky, J.; Babkova, P.; Degtjarik, O.; Fortova, A.; Gora, A.; Iermak, I.; Rezacova, P.; Dvorak, P.; Kuta Smatanova, I.; Prokop, Z.; Chaloupkova, R.; Damborsky, J. Engineering a de Novo Transport Tunnel. ACS Catal 2016, 6, 7597–7610, doi:10.1021/acscatal.6b02081. ARTICLE
Kozlikova, B.; Sebestova, E.; Sustr, V.; Brezovsky, J.; Strnad, O.; Daniel, L.; Bednar, D.; Pavelka, A.; Manak, M.; Bezdeka, M.; Benes, P.; Kotry, M.; Gora, A.; Damborsky, J.; Sochor, J. CAVER Analyst 1.0: Graphic tool for interactive visualization and analysis of tunnels and channels in protein structures. Bioinformatics 2014, 30, 2684–2685, doi:10.1093/bioinformatics/btu364. ARTICLE.
Gora, A.; Brezovsky, J.; Damborsky, J. Gates of enzymes. Chem Rev 2013, 113, 5871–5923, doi:10.1021/cr300384w. ARTICLEOpen Access
Hasan, K.; Gora, A.; Brezovsky, J.; Chaloupkova, R.; Moskalikova, H.; Fortova, A.; Nagata, Y.; Damborsky, J.; Prokop, Z. The effect of a unique halide-stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58. In FEBS Journal; 2013; Vol. 280, pp. 3149–3159.
Brezovsky, J.; Chovancova, E.; Gora, A.; Pavelka, A.; Biedermannova, L.; Damborsky, J. Software tools for identification, visualization and analysis of protein tunnels and channels. Biotechnol Adv 2013, 31, 38–49. ARTICLE
Chovancova, E.; Pavelka, A.; Benes, P.; Strnad, O.; Brezovsky, J.; Kozlikova, B.; Gora, A.; Sustr, V.; Klvana, M.; Medek, P.; Biedermannova, L.; Sochor, J.; Damborsky, J. CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures. PLoS Comput Biol 2012, 8, doi:10.1371/journal.pcbi.1002708. ARTICLEOpen Access
Biedermannová, L.; Prokop, Z.; Gora, A.; Chovancová, E.; Kovács, M.; Damborský, J.; Wade, R. C. A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB. J Biol Chem 2012, 287, 29062–29074, doi:10.1074/jbc.M112.377853.
Artur.Gora(at)polsl.pl
or
a.gora(at)tunnelinggroup.pl